New toolkits have been developed to enable cell-type-specific manipulation of CCT genes with remarkable efficiency while also uncovering the role of CNMa signal in regulating morning anticipation.
The split mNeonGreen system enables fast and efficient endogenous tagging in human iPSCs and facilitates the study of proteins in human stem cells and differentiated cells by live imaging.
Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
Integration of language model and geometric deep learning enables accurate and efficient genome-scale annotation of comprehensive protein-ligand binding sites.
Behzad Yaghmaeian Salmani, Laura Lahti ... Thomas Perlmann
Single nuclei RNA sequencing unmasks 16 variants of midbrain dopamine neurons within a continuum of their gene expression landscape and resolves their differential vulnerability.
Jonathan Zirin, Barbara Jusiak ... Norbert Perrimon
A CRISPR knock-in approach enables the efficient generation of tissue-specific LexA and QF driver lines which can simultaneously control gene expression in multiple tissues.
Arthur L Schneider, Rita Martins-Silva ... Nuno L Barbosa-Morais
voyAGEr is an online platform that facilitates the exploration of age-related gene expression dynamics in human tissues, allowing users to analyse tissue- and sex-specific changes alongside donor medical histories.
