Controlling cell migration

Latest research

1. 1. Structural Biology and Molecular Biophysics

   Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies

   Christian Galicia, Giambattista Guaitoli ... Wim Versées

   Conformation-specific nanobodies enable to capture and solve the first GTP-bound active structure of a bacterial homolog of the Parkinson-associated LRRK2 protein, providing insights into the activation mechanism of these proteins.
2. 1. Developmental Biology
   2. Structural Biology and Molecular Biophysics

   Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

   Arne Elofsson, Ling Han ... Luca Jovine

   AlphaFold-Multimer was used to investigate extracellular protein interactions involved in mammalian egg-sperm recognition, suggesting a putative pentameric complex that includes TMEM81, a sperm protein not previously involved in gamete recognition.
3. 1. Cell Biology
   2. Neuroscience

   KIS counteracts PTBP2 and regulates alternative exon usage in neurons

   Marcos Moreno-Aguilera, Alba M Neher ... Carme Gallego

   KIS, a kinase upregulated in the developmental brain, phosphorylates the PTBP2 splicing complex and modulates alternative exon usage for proper synaptic spine emergence and maturation.
4. 1. Neuroscience

   Episodic long-term memory formation during slow-wave sleep

   Flavio J Schmidig, Simon Ruch, Katharina Henke

   Sleep-encoded vocabulary influences awake decision-making 36 hr later, particularly when targeting the vocabulary to slow-wave troughs, which suggests that unconscious episodic memory formation during deep sleep is possible.
5. 1. Stem Cells and Regenerative Medicine

   Disease modeling and pharmacological rescue of autosomal dominant retinitis pigmentosa associated with RHO copy number variation

   Sangeetha Kandoi, Cassandra Martinez ... Deepak A Lamba

   Stem cell-derived retinal organoids are a useful tool to understand the pathobiology of devastating retinal degenerations and can aid to identify and validate therapeutics to promote rescue.
6. 1. Medicine

   Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

   Anika Shimonty, Fabrizio Pin ... Lynda F Bonewald

   Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
7. 1. Cell Biology

   Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice

   Ang Li, Jianxun Yi ... Jingsong Zhou

   The distinct transcriptomic features of extraocular muscle satellite cells, partially mimicked by NaBu treatment, endow enhanced self-renewal and axon attraction, contribute to neuromuscular junction preservation during ALS progression.
8. 1. Cell Biology

   Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling

   Simona Bolamperti, Hiroaki Saito ... Hanna Taipaleenmäki

   A novel mechanism underlying the regulation of osteoblast morphology, adherence, and migration that has implications in bone remodeling, regeneration, and response to the pharmacological effects of PTH treatment.
9. 1. Cell Biology
   2. Neuroscience

   Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

   Mariana I Tsap, Andriy S Yatsenko ... Halyna R Shcherbata
10. 1. Neuroscience

    Emergence of brain-like mirror-symmetric viewpoint tuning in convolutional neural networks

    Amirhossein Farzmahdi, Wilbert Zarco ... Tal Golan