Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

    Matias I Autio, Efthymios Motakis ... Roger SY Foo
    Depiction of novel human genomic safe harbour loci that have been validated in vitro for safety and stable expression in human embryonic stem cells and cell types from all the three germ lineages.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

    Jesus A Castor-Macias, Jacqueline A Larouche ... Carlos A Aguilar
    The treatment of injury from volumetric muscle loss with Maresin 1 reduces inflammation and fibrosis, driving improvements in the recovery of muscle strength.
    1. Stem Cells and Regenerative Medicine

    An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

    J Barney Bryson, Alexandra Kourgiantaki ... Linda Greensmith
    Stem-cell-based neural replacement, in combination with optogenetic stimulation, could represent a translationally viable therapeutic strategy to overcome atrophy and paralysis of targeted muscles in people living with amyotrophic lateral sclerosis.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

    Lutian Yao, Jiawei Lu ... Maurizio Pacifici
    Activation of Activin A-expressing progenitor cells emerges as a pivotal mechanism in bone fracture healing, shedding light on a potential therapeutic avenue to augment bone repair processes.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Microstructural differences in the osteochondral unit of terrestrial and aquatic mammals

    Irina AD Mancini, Riccardo Levato ... Jos Malda
    Analysis of the osteochondral unit of aquatic mammals reveals a distinctly different tissue structure, lacking the arcade-like collagen fiber organization, a calcified cartilage layer and a dense subchondral bone plate, typically seen in osteochondral tissue of terrestrial mammals.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    BRAIDing receptors for cell-specific targeting

    Hui Chen, Sung-Jin Lee ... Yang Li
    A novel strategy to activate the WNT pathway in a cell type selective manner by linking designer ligands with target cell specific bridging receptors.